Anti-cancer research

Paclitaxel, >99.5%, 100% Natural extract                  For research only

         

M.W. 853.92

C47H51NO14

[33069-62-4]

M.I. 12:  7117

Storage:  Store at or below -20 ºC.   Solubility:  Soluble in DMSO or ethanol.  Disposal:  A

• Antitumor and antileukemic agent isolated from the bark of the yew tree, Taxus brevifolia.  Wani,

• Binds to β-tubulin and promotes the assembly of microtubules that resist depolymerization preventing normal cell division.  

• Induces apoptosis through a JNK-dependent pathway in the early phase followed by a JNK-independent pathway that results in Bcl-2 phosporylation.  
•             

Paclitaxel, >99.5%, Natural extract

M.C., et al.  "Plant antitumor agents.  VI.  The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia." J. of Amer. Chem. Soc. 93:  2325-2327 (1971).  

McGuire, W., et al.  "Taxol:  a unique antineoplastic agent with significant activity in advanced ovarian neoplasms." Ann. Int. Med. 111:  273-279 (1989).

Rowinsky, E.K., et al.  "Taxol:  a novel investigational antimicrotubule agent." Int. J. Cancer 82:  1247-1259 (1990).  

Parekh, H. and Simpkins, H.  "The transport and binding of taxol." Gen. Pharmacol. 29:  167-172 (1997).  

Jordan, A., et al.  "Tubulin as a target for anticancer drugs:  agents which interact with the mitotic spindle investigational antimicrotubule agent." Med. Res. Rev. 18:  259-296 (1998).

Wang, T.H., et al.  "Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-termnial kinase (JNK)-dependent and -independent pathways in overian cancer cells." J. Biol. Chem. 274:  8208-8216 (1999).  

Shtil, A.A., et al.  "Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells." Oncogene 18:  377-384 (1999).  

Srivastava, R.K. et al.  "Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase." Mol. Cell. Biol. 18:  3509-3517 (1998).  

Torres, K., and Horwitz, S.B.  "Mechanisms of Taxol-induced cell death are concentration dependent." Cancer Res. 58:  3620-3626 (1998). 

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