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Taken as a nutritional supplement, chitosan dissolves in the stomach and mixes with the dietary fat. Being a dietary fiber, chitosan increases the viscosity, giving a filling effect(1,2). From the stomach, the dietary fats are passed on to the small intestine. In the small intestine, bile acids are released and later reabsorbed. Bile acids solubilize the fat and decreases the fat droplet size to what is ca;;ed micelles. chitosan binds to the micelles and disturbs the structure of the fat-bile acid complex (3,4). Pancreatic Lipase is an enzyme also released in the small itestine, which breaks down micellic fat into free fatty asids and monoglycerids. Chitosan partly inhibits this enzyme, and thereby reduces the fat digestion (5). Bile acids mainly consist of cholesterol, and is normally reabsorbed in the small intestine. In addition to binding fatty acids and monoglyserids, chitosan thereby directly reduces the uptake of cholesterol, reducing the total blood cholesterol level (7). This process is called bile acid sequestration. Chitosan with a high degree of deacetylation increases the capacity to bind dietary fat and bile acids. Chitosan-bound fat and bile acids are excreted in the stool (2). Chiotsan’s abilities to reduce weight, cholesterol blood levels and atherosclerosis have been demonstrated in several clinical studies (8-12).

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